Mutations in the MEN I gene in sporadic neuroendocrine tumours of gastroenteropancreatic system.
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چکیده
منابع مشابه
THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN
MeduIIary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for g...
متن کاملGuidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours.
Correspondence to: Dr J Ramage, North Hampshire Hospital, Aldermaston Road, Basingstoke, Hants, UK; johnramage1@ compuserve.com . . . . . . . . . . . . . . . . . . . . . . . 1.0 SUMMARY OF RECOMMENDATIONS 1.1 Genetics N Clinical examination to exclude complex cancer syndromes (for example, multiple endocrine neoplasia 1 (MEN1)) should be performed in all cases of neuroendocrine tumours (NETs), ...
متن کامل[Associated gastroenteropancreatic neuroendocrine tumours to familiar syndromes].
Aproximately 5-10% of neuroendocrine tumours (NETs) of the gastroenteropancreatic system (GEP) have an hereditary background. The known hereditary syndromes include: multiple endocrine neoplasia type 1 (MEN 1), von Hippel Lindau disease (VHL), neurofibromatosis type 1 (NF 1) and tuberous sclerosis complex (TSC). This review discusses for each of these syndromes the: genes involved and specifics...
متن کاملAnalysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation.
BACKGROUND Chromosomal instability is observed in a wide spectrum of human cancer syndromes. However, to date, little is known of the characteristic genetic changes in sporadic neuroendocrine tumours of the gastroenteropancreatic system. AIMS AND METHOD We have studied copy number aberrations (CNAs) in 26 sporadic neuroendocrine tumours of the enteropancreatic system (12 foregut and 14 midgut...
متن کامل[Genetic profile of gastroenteropancreatic neuroendocrine tumors].
Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms but their incidence has significantly increased in the last 30 years. These tumors are usually sporadic but can also occur as part of certain endocrine tumor susceptibility syndromes such as multiple endocrine neoplasia type1 (MEN1) and von Hippel Lindau disease. The genetic abnormalities associated with the development ...
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عنوان ژورنال:
- Lancet
دوره 350 9086 شماره
صفحات -
تاریخ انتشار 1997